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Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest |
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| Authors: | Pan Ende Harinantenaina Liva Brodie Peggy J Callmander Martin Rakotonandrasana Stephan Rakotobe Etienne Rasamison Vincent E Tendyke Karen Shen Yongchun Suh Edward M Kingston David G I |
| Affiliation: | a Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States b Missouri Botanical Garden, B. P. 3391, Antananarivo 101, Madagascar c Centre National d’Application et Recherches Pharmaceutiques, B. P. 702, Antananarivo 101, Madagascar d Next Generation Systems, Eisai Inc., 4 Corporate Drive, Andover, MA 01810, United States |
| Abstract: | Investigation of the endemic Madagascar plant Leptadenia madagascariensis Decne. (Apocynaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the four new cardenolides 1-4. The structure elucidations of these compounds were based on analyzes of their 1D and 2D NMR spectra and mass spectrometric data. The cardenolides were strongly antiproliferative to the A2780 ovarian cancer cell line, with IC50 values of 0.18, 0.21, 0.17, and 0.29 ??M line, and to the H460 human lung cancer cell line, with IC50 values of 0.16, 0.68, 0.37, and 0.48 ??M, respectively. |
| Keywords: | Antiproliferative activity Cardenolide Biodiversity NMR |
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