Dibenzocyclooctadiene lignans from Kadsura philippinensis |
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Authors: | Ya-Ching Shen Yu-Chi Lin Michael Y Chiang Ashraf Taha Khalil |
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Institution: | a School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Sec. 1, Taipei 100, Taiwan b Institute of Marine Resources, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 80424, Taiwan c Department of Chemistry, National Sun Yat-Sen University, Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 80424, Taiwan d Department of Pharmacy, Tajen University, Yen-Pou, Ping Tung Shien, Taiwan |
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Abstract: | Lignans with the dibenzocyclooctadiene skeleton, kadsuphilols I-L, and one C19-homolignan, kadsuphilol M, were isolated by chromatographic fractionation of an ethyl acetate extract of the aerial parts of Kadsura philippinensis. Their structures were elucidated through extensive spectroscopic methods, including HRESIMS and 2D NMR experiments (HMQC, COSY and HMBC). The stereochemistry at the chiral centers and the biphenyl moist, were determined using NOESY, as well as analysis of CD spectra, respectively. The relative configuration of heteroclitin J was confirmed by single crystal X-ray crystallographic analysis. The in vitro radical-scavenging activities of these compounds by using DPPH were evaluated. |
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Keywords: | Kadsura philippinensis Schisandraceae Lignans Dibenzocyclooctadiene Homolignans Antioxidative activity |
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