Chromones from the tubers of Eranthis cilicica and their antioxidant activity |
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Authors: | Minpei Kuroda Singo Uchida Yoshihiro Mimaki |
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Institution: | a School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan b Faculty of Pharmaceutical Science, Aomori University, 2-3-1, Koubata, Aomori, Aomori 030-0943, Japan |
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Abstract: | Chemical studies on the constituents of Eranthis cilicica led to isolation of ten chromone derivatives, two of which were previously known. Comprehensive spectroscopic analysis, including extensive 1D and 2D NMR data, and the results of enzymatic hydrolysis allowed the chemical structures of the compounds to be assigned as 8,11-dihydro-5-hydroxy-2,9-dihydroxymethyl-4H-pyrano2,3-g]1]benzoxepin-4-one, 5,7-dihydroxy-8-(2E)-4-hydroxy-3-methylbut-2-enyl]-2-methyl-4H-1-benzopyran-4-one, 5,7-dihydroxy-2-hydroxymethyl-8-(2E)-4-hydroxy-3-methylbut-2-enyl]-4H-1-benzopyran-4-one, 7-(β-d-glucopyranosyl)oxy]-5-hydroxy-8-(2E)-4-hydroxy-3-methylbut-2-enyl]-2-methyl-4H-1-benzopyran-4-one, 7-(β-d-glucopyranosyl)oxy]-5-hydroxy-2-hydroxymethyl-8-(2E)-4-hydroxy-3-methylbut-2-enyl]-4H-1-benzopyran-4-one, 9-(O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl)oxy]methyl-8,11-dihydro-5,9-dihydroxy-2-methyl-4H-pyrano2,3-g]1]benzoxepin-4-one, 8,11-dihydro-5,9-dihydroxy-9-hydroxymethyl-2-methyl-4H-pyrano2,3-g]1]benzoxepin-4-one, and 7-(O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl)oxy]methyl-4-hydroxy-5H-furo3,2-g]1]benzopyran-5-one, respectively. The isolated compounds were evaluated for their antioxidant activity. |
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Keywords: | Eranthis cilicica Ranunculaceae Chromones Glycosides Antioxidant activity |
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