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Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae) |
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| Authors: | Guillaume Marti Christian Moretti Soizic Prado Pascal Retailleau Marc Litaudon |
| Affiliation: | a Institut de Chimie des Substances Naturelles, 1, avenue de la Terrasse, CNRS, 91198 Gif-sur-Yvette, France b UPS 2561, CNRS, 16, avenue André Aron, 97300 Cayenne, Guyane Française, France c Unité N° 84 de l’IRD: Biodival, IRD, Technoparc, 5, rue du Carbone, 45072 Orleans Cedex 2, France d Museum National d’Histoire Naturelle, USM504-EA3335, CP52, 61, rue Buffon, 75231 Paris Cedex 05, France e Museum National d’Histoire Naturelle, USM502-UMR 5152 CNRS, 63, rue Buffon, 75231 Paris Cedex 05, France |
| Abstract: | In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10 μg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3 μM to 37.2 μM. |
| Keywords: | Moronobea coccinea Clusiaceae Benzophenone Coccinone Antiplasmodial |
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