The stoichiometry of ion fluxes during Sr2+-induced oscillations in mitochondria |
| |
| Authors: | Y.V. Evtodienko V.P. Zinchenko E.L. Holmuhamedov A.V. Gylkhandanyan A.M. Zhabotinsky |
| |
| Affiliation: | Institute of Biological Physics, Academy of Sciences of the USSR, Pushchino and Institute of Biological Testing of Chemical Compounds, Kupavna, Moscow Region U.S.S.R. |
| |
| Abstract: | A quantitative study of H+, K+, Sr2+ and succinate fluxes in Sr2+-induced oscillatory state of rat liver mitochondria is presented. It was shown that oscillation of succinate content in mitochondria occurs synchronously with oscillations of the cation fluxes. Total charge transferred across the membrane by the registered cations and the succinate-anion is equal to zero. Passive H+-influx has been calculated at all stages of the oscillatory cycle. The conclusion is made that electroneutral 2 H+/Sr2+ exchange is periodically induced in mitochondria. A value of (2 ± 0.2) · 10-7 mol Sr2+/min per mg protein. has been determined for Sr2+ by this type of exchange. |
| |
| Keywords: | Ion flux stoichiometry Charge transfer (Mitochondrial membrane) |
| 本文献已被 ScienceDirect 等数据库收录！ |
