Differential elongation of autosomal pachytene bivalents related to their DNA content in human spermatocytes |
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| Authors: | J M Luciani M R Guichaoua P Cau B Devictor N Salagnon |
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| Institution: | (1) Laboratoire d'Embryologie et de Cytogénétique, Faculté de Médecine, Secteur Nord, Boulevard Pierre Dramard, F-13326 Marseille, Cédex 15, France;(2) Laboratoire de Biologie et d'Histologie, INSERM U 172, CNRS UA 1179, Faculté de Médecine, Secteur Nord, Boulevard Pierre Dramard, F-13326 Marseille, Cédex 15, France;(3) Laboratoire de Neuropathologie, Faculté de Médecine de Marseille, Boulevard Jean Moulin, F-13385 Marseille, Cédex 5, France |
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| Abstract: | The establishment of the complete karyotype of human pachytene spermatocytes reveals differences in stretching of chromosomes between meiosis and mitosis. Bivalents or specific regions of bivalents which exhibit many R-bands are particularly elongated. In mitotic chromosomes, the DNA contained in such bands is known to be early replicating. The study of variations in the total length and the centromeric index of bivalent 1 suggests that differential elongation of pachytene bivalents is a premeiotic event, taking place during the last DNA replication. |
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