Collagen biochemistry of osteopetrotic bone: I. Quantitative changes in bone collagen cross-links in virus-induced avian osteopetrosis |
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| Authors: | Albert J. Banes Paul H. Bernstein Ralph E. Smith Gerald L. Mechanic |
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| Affiliation: | 1. Dental Research Center University of North Carolina Chapel Hill, N. C. 27514 USA;2. Department of Biochemistry and Nutrition University of North Carolina Chapel Hill, N. C. 27514 USA;3. Department of Microbiology and Immunology Duke University Durham, North Carolina 27710 USA |
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| Abstract: | The patterns of [3H]-NaBH4-reduced bone collagen cross-links from osteopetrotic chickens were compared with those of age-matched controls. Ratios of the reduced cross-links, dihydroxylysinonorleucine (DHLNL)1 to hydroxylysinonorleucine (HLNL), were dramatically increased in tibia bone samples from osteopetrotic birds compared to values from control birds. In addition, the initial HLNL peak from osteopetrotic bone collagen was heterogeneous, whereas DHLNL from osteopetrotic or normal bone collagen and HLNL from normal bone collagen were homogeneous. |
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