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Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells |
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| Authors: | Zhengmei Yang Youquan Bu Changdong Wang Geli Liu Fangzhou Song |
| Institution: | 1. Department of Pharmacology, L.M. College of Pharmacy, P.O. Box 4011, Navrangpura, Ahmedabad, 380 009, India 3. Department of Pharmacy, Faculty of Technology and Engineering, The M.S. University of Baroda, Kala Bhavan, Vadodara, 390 001, India 2. B.V. Patel Pharmaceutical Education and Research Development Center, Thaltej, Ahmedabad, 380 054, India |
| Abstract: | Diabetic nephropathy (DN) is one of the foremost causes of renal failure and a primary cause of diabetes mellitus related death. Previously, we have reported that aqueous extract of Enicostemma littorale has potential antidiabetic activity. In the present study, we have investigated the effect of aqueous extract of E. littorale 1 g/kg, p.o. and swertiamarin 50 mg/kg, p.o. daily for 3 weeks in type 1 DN complications in SD rats. DN was assessed by serum urea, creatinine, lipid profile and water intake levels. Treatment with aqueous extract of E. littorale and swertiamarin significantly decreased serum urea and creatinine and other parameters associated with the development of DN in type 1 diabetic rats. We have also found considerable improvement in histology of glomerular function of aqueous extract of E. littorale and swertiamarin-treated animals. |
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