血管紧张素转化酶抑制肽的研究进展

血管紧张素转化酶 (angiotensin I convertingenzyme ,ACE)在血压调节方面起着重要的作用 ,当其受到抑制时血压就会降低。许多合成的ACE抑制剂被广泛地应用于临床 ,但会造成多种副作用。近年来 ,对天然ACE抑制肽的研究表明 ,一些来源于蛋白酶解产生的活性肽可以对ACE起到有效的抑制作用。综述了血管紧张素转化酶的抑制肽的降压原理 ,种类和来源以及结构特点等的研究进展 ,并对其应用前景进行了展望。

Research Progress in Inhibitory Peptides of Angiotensin Converting Enzyme

Angiotensin-I-converting enzyme (ACE) plays an important physiologic role in the blood pressure regulation. Specific inhibitors of ACE have shown itself to be useful as antihypertensive drugs. Many synthetic ACE inhibitors are available for clinical use, but some undesirable side effects may occur. Recently, there has been a trend toward development of natural ACE inhibitory peptides generated during enzymatic hydrolysis of various proteins. The active peptides from protein have significant antihypertensive effect, which is realized by inhibiting ACE activation. The research progresses of the ACE inhibitory peptides were reviewed, and their wide developmental prospects were also forecasted.;