HNHDb: A database on pattern based classification of HNH domains reveals functional relevance of sequence patterns and domain associations. |
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| Authors: | Alaguraj Veluchamy Sujitha Mary Vishal Acharya Preethi Mehta Taru Deva Sankaran Krishnaswamy |
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| Affiliation: | Center of Excellence in Bioinformatics, School of biotechnology, Madurai Kamaraj University, Madurai, India |
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| Abstract: | The HNH Database is a collection and sequence-based classification of HNH domain proteins. The database contains about 1913 HNH
domain containing proteins, and is classified into 10 subsets based on the sequence pattern. Each of these subsets has unique signature
sequences. We have shown a correlation between the subset combination and their domain association and function. Functional divergence
of this domain may be due to the combination of these conserved patterns and the large variations in the non-conserved regions. HNHDb is
freely available at http://bicmku.in:8081/hnh. |
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| Keywords: | HNH domains HNHDb sequence classification |
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