Synthesis of a novel fluorescent probe for estrogen receptor |
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| Authors: | Adamczyk Maciej Reddy Rajarathnam E Yu Zhiguang |
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| Institution: | Department of Chemistry (9NM, Bldg AP20), Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6016, USA. maciej.adamczyk@abbott.com |
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| Abstract: | A novel estradiol-mimetic fluorescent probe 5 was synthesized from diethylstilbestrol (DES, 1), which is useful for probing estrogen receptor (ERalpha), a prognostic indicator of estrogen-dependent cancers, and for developing a homogeneous fluorescence polarization (FP) assay to identify the ligands of estrogen receptor. |
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