Drugs, hERG and sudden death |
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Authors: | Brown A M |
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Institution: | MetroHealth Campus, Case Western Rreserve University, Cleveland, OH 44128, USA. abrown@chantest.com |
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Abstract: | Early recognition of potential QT/TdP liability is now an essential component of the drug discovery/drug development program. The hERG assay is an indispensable step and a high-quality assay must accompany any investigational new drug (IND) application. While it is the gold standard at present, the hERG assay is too labor-intensive and too low throughput to be used as a screen early in the discovery/development process. A variety of indirect high throughput screens have been used. |
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Keywords: | Screens Throughput hERG QT Sudden death |
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