调控通路内基因表达的相关性分析

本研究从基因表达调控通路的角度分析了基因功能与基因表达之间的关系，利用7套酿酒酵母基因芯片表达谱数据和通路数据库（KEGG和CYGD）所提供的信息，应用我们研制的Genehub软件分析研究了同一基因表达调控通路内的基因在mRNA表达水平上的相关性，共涉及16条通路，495个基因。通过Pearson相关系数和Spearman相关系数两种相似性测度的分析，我们发现有94%（15条）的基因表达调控通路内的基因在大于等于4套的表达谱数据中是共表达的，以上结果从基因表达调控通路的角度，证实了基因功能与基因表达之间存在着一定的相关性。

Analysis of the mRNA expression similarity of genes in the same gene expression regulatory pathway

In this work we analysed the relationship of gene expression from the point of view of gene expression regulatory pathway. Using seven sets of Saccharomyces cerevisiae gene chip expression profile data, and information from two pathway database (KEGG and CYGD), we analysed the mRNA expression similarity of genes in the same gene expression regulatory pathway by Genehub software, that involved totally 16 pathways with more than 495 genes. From the calculation of two different similarity measures-Pearson correlation coefficient and Spearman correlation coefficient, we found that about 94 percent of gene expression regulatory pathways are correlatively expressed in more than 4(including 4) sets of expression profile data, and it presents additional evidence for the correlation between gene function and its expression in the view of gene expression regulatory pathways.