The development of a new strain of spontaneously hypertensive rats |
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| Authors: | G Bianchi U Fox E Imbasciati |
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| Affiliation: | Istituto di Clinica Medica I e Sezione di Nefropatologia dell''Istituto di Urologia dell''Università di Milano, Laboratori di Farmacologia della Lepetit S.p.A., Milano, Italy |
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| Abstract: | Spontaneously hypertensive rats (SHR) have been obtained by selective inbreeding of rats with high blood pressure. Hypertension develops in these rats soon after weaning, and blood pressure plateaus at approximately 50–60 days of age to remain stable or slightly decrease thereafter. With respect to control normotensive rats, concurrently developed by breeding normal blood pressure rats, a significantly higher organ weight/body weight ratio for heart and kidneys was found in SHR. This ratio for adrenals is higher but not statistically different. No difference was demonstrable in regard to kidney and adrenal histological appearance. |
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