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Cinnamomin a Versatile Type Ⅱ Ribosome-inactivating Protein
引用本文:Xu H,Liu WY. Cinnamomin a Versatile Type Ⅱ Ribosome-inactivating Protein[J]. Acta biochimica et biophysica Sinica, 2004, 36(3): 169-176
作者姓名:Xu H  Liu WY
作者单位:Hong XU and Wang-Yi LIU State Key Laboratory of Molecular Biology,the Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,the Chinese Academy of Sciences,320 Yueyang Road,Shanghai 200031,China
摘    要:
Ribosome-inactivating proteins (RIPs) are a groupof ribotoxins widely distributed in the plant kingdomas well as in certain fungi, algae and bacteria. RIPs havebeen thoroughly reviewed in references [1–6]. Theseproteins act as RNA N-glycosidase (rRNA N-glycosidase,EC 3.2.2.22) to specifically remove an adenine fromthe universally conserved sarcin/ricin domain (S/R domain)of the largest RNA in ribosome [7–9] and to render itincapable of carrying out protein synthesis (Fig. 1). Based …

关 键 词:核糖体抑制蛋白 变性 八叠球菌 篦麻毒素 结构功能域

Cinnamomin--a versatile type II ribosome-inactivating protein
Xu Hong,Liu Wang-Yi. Cinnamomin--a versatile type II ribosome-inactivating protein[J]. Acta biochimica et biophysica Sinica, 2004, 36(3): 169-176
Authors:Xu Hong  Liu Wang-Yi
Affiliation:State Key Laboratory of Molecular Biology, the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
Abstract:
Ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can specifically act on the universally conserved sarcin/ricin domain (S/R domain) of the largest RNA in ribosome and thus irreversibly inactivate ribosome for protein synthesis. Cinnamomin is a multifunctional type II RIP isolated in our laboratory from the mature seeds of the camphor tree. This protein has been extensively studied with regard to its purification, characteristics, structure and function, genetic expression, enzymatic mechanism, physiological role in seed cell and toxicity to cancer cells and insect larvae. The research results of cinnamomin obtained in our laboratory are summarized in this review. Understanding of cinnamomin and the relative new proteins will help expand our knowledge of RIPs and may accelerate theoretical study and the development of their potential applications.
Keywords:cinnamomin  cinphorin  ribosome-inactivating protein
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