Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance. |
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| Authors: | D Fallows R B Kent D L Nelson J R Emanuel R Levenson D E Housman |
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| Affiliation: | Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139. |
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| Abstract: | ![]()
We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase alpha 1 subunit gene was detected, suggesting that structural differences between the rodent and primate alpha 1 subunits determine the different ouabain sensitivities. |
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