Effect of synthetic hydroxy isothiocyanates on a bacterial virus and DNA |
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Authors: | Tajima Hirokuni Nakamoto Yoshiaki Taketo Akira |
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Institution: | Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan. hi-tajima@rengo.co.jp |
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Abstract: | The Effect of hydroxy isothiocyanates on a bacterial virus and M13 DNA was examined. Hydroxy-substituted phenyl and phenyl alkyl isothiocyanates, especially 2-(3,4-dihydroxyphenyl)ethyl isothiocyanate(IT-Dop) synthesized from dopamine, showed antiviral activity on psiK. In transfection experiments with M13 mp DNA species, IT-Dop inhibited the single-stranded (SS) molecule more effectively than the double stranded replicative form (RF) DNA. These effects were dependent on reaction time, and on IT-Dop concentration. An additional experiment indicated that treatment with IT-Dop suppressed annealing (reassociation) of denatured DNA. These results indicate that IT-Dop reacts mildly with virus and SS DNA. |
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