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Reduction of 7-ketolithocholic acid to chenodeoxycholic acid by rat liver preparations in vitro |
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| Authors: | Y Amuro W Yamade T Nakano E Hayashi T Hada K Higashino |
| Abstract: | The formation of chenodeoxycholic acid via 7-ketolithocholic acid by rat liver preparations was examined in vitro. Results showed that a rat liver preparation reduced 7-ketolithocholic acid mainly to chenodeoxycholic acid and to ursodeoxycholic acid in a smaller amount, and that the reductase required NADPH but not NADH as coenzyme and was mainly localized in the microsomes. |
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