| Atypical responses to morphine in mice: a possible relationship to anorexia nervosa? |
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Atypical responses to morphine in mice: A possible relationship to anorexia nervosa? |
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| M Buck,M A Marrazzi. Atypical responses to morphine in mice: A possible relationship to anorexia nervosa?[J]. Life sciences, 1987, 41(6): 765-773. DOI: 10.1016/0024-3205(87)90457-7 |
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| Authors: | M Buck M A Marrazzi |
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| Affiliation: | 1. Department of Biological Sciences, University of Waikato, Hamilton, New Zealand;2. Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55114, USA;1. Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Feixa Llarga s/n, 08907 Hospitalet del Llobregat, Barcelona, Spain;2. Ciber Fisiopatologia Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Barcelona, Spain;3. Dep. Psicobiologia i Metodologia, Facultat de Psicologia, Universitat Autonoma de Barcelona, Carrer de Ca n''Altayó s/n, 08193 Bellaterra, Barcelona, Spain |
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| Abstract: | According to our previously proposed auto-addiction hypothesis of chronic anorexia nervosa, patients become addicted to an initial period of dieting through endogenous opioid mediated mechanisms. Morphine causes hyperactivity and anorexia in the mouse, symptoms of anorexia nervosa but responses opposite to those of most species including rats and normal human subjects. This suggests that the atypical opioid systems in the mouse may resemble those of the chronic anorexia nervosa patient in contrast to those of most species including the normal human. Characterization of this atypical opioid system may be useful in understanding the pathophysiology of anorexia nervosa. |
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