Mechanism of action of the nitrosoureas: formation of 1,2-(diguanosin-7-yl) ethane from the reaction of BCNU (1,3-bis-[2-chloroethyl]-1-nitrosourea) with guanosine |
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| Authors: | C T Gombar W P Tong D B Ludlum |
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| Institution: | Department of Pharmacology and Experimental Therapeutics, Albany Medical College, Albany, New York 12208 USA |
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| Abstract: | A crosslinked dinucleoside, 1,2-(diguanosin-7-yl) ethane, has been isolated from the reaction of guanosine with the antitumor agent, BCNU. The formation of this product suggests that DNA crosslinking, which may be responsible for the cytotoxicity of BCNU, could occur through such dinucleosides. |
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| Keywords: | To whom correspondence should be addressed at the Albany Medical College |
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