In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes |
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| Authors: | Caballero Ana B Marín Clotilde Rodríguez-Diéguez Antonio Ramírez-Macías Inmaculada Barea Elisa Sánchez-Moreno Manuel Salas Juan M |
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| Affiliation: | a Departamento de Química Inorgánica, Universidad de Granada, Severo Ochoa s/n, E-18071, Granada, Spainb Departamento de Parasitología, Universidad de Granada, Severo Ochoa s/n, E-18071, Granada, Spain |
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| Abstract: | Conventional reactions of the versatile multidentate ligand 5-methyl-1,2,4-triazolo[1,5-a] pyrimidin-7(4H)-one (HmtpO) with metallic(II) perchlorate salts lead to three novel multidimensional complexes [Cu(HmtpO)2(H2O)3](ClO4)2·H2O (1), {[Cu(HmtpO)2(H2O)2](ClO4)2 ·2HmtpO}n (2) and {[Co(HmtpO)(H2O)3](ClO4)2·2H2O}n (3). We have tested the antiparasital activity in vitro and in vivo of the three new complexes against Trypanosoma cruzi showing very promising results and overcoming clearly the reference drug commonly used for the Chagas disease treatment, benznidazole. |
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| Keywords: | Trypanosoma cruzi Coordination chemistry Biological properties |
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