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Synthesis of new azino fused benzimidazolium salts. a new family of DNA intercalating agents. I |
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| Authors: | Joaquín Pastor Jorge Sir JosL García-Navío Juan J Vaquero M Melia Rodrigo Milagros Ballesteros Julio Alvarez-Builla |
| Institution: | a Departmentos de Química Orgánica Universidad de Alcalá de Henares. 28871 Alcalá de Henares., Madrid., Spain b Departanento de Química Física Universidad de Alcalá de Henares. 28871 Alcalá de Henares., Madrid., Spain c Departamento de Quimica Analítica. Universidad de Alcalá de Henares. 28871 Alcalá de Henares., Madrid., Spain |
| Abstract: | A series of new pyrido1,2-a]- and pyridazino1,6-a]benzimidazolium salts have been synthesized from readily available 1,3-disubstituted 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity versus HT-29 have been tested. The initial results show that the title compounds are a new family of intercalating agents. |
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