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Endothelin-1 response to mental stress in early ischemic lesions of the extremities due to systemic sclerosis
Authors:Fontana Fiorella  Bernardi Pasquale  Lanfranchi Giuseppina  Conti Eleonora  Spampinato Santi  Di Toro Rosanna  Bonafè Francesca  Coccheri Sergio
Affiliation:

aDipartimento di Medicina Interna, Cardioangiologia, Epatologia, Ospedale S. Orsola, Via Massarenti 9, 40138 Bologna, Italy

bDipartimento Cardiovascolare, Ospedale S. Orsola, Via Massarenti 9, 40138 Bologna, Italy

cDipartimento di Farmacologia, Via Irnerio 48, 40126 Bologna, Italy

dDipartimento di Biochimica, Via Irnerio 48, 40126 Bologna, Italy

Abstract:
We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P < 0.01) in blood pressure, heart rate, endothelin-1 and catecholamine levels, whereas it did not change the low basal levels of nitric oxide. In healthy subjects (n = 20) the test significantly (P < 0.01) decreased endothelin-1 without affecting nitric oxide. The low basal levels of nitric oxide and the high plasma concentration of endothelin-1 after psychological stress cannot be explained by an impaired release from the limited ischemic lesions alone. This suggests a diffuse microvascular derangement that aggravates the course of peripheral microvascular ischemic lesions.
Keywords:Limb ischemia   Systemic sclerosis   Mental arithmetic test   Endothelin-1   Nitric oxide   Norepinephrine
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