Ultrashort echo time T21 values decrease in tendons with application of static tensile loads |
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| Institution: | 1. Department of Radiology, University of California, San Diego, CA, USA;2. Department of Histology and Embryology, Jinan University, Guangzhou, China;3. GE Healthcare, San Diego, CA, USA;4. Radiology Service, VA San Diego Healthcare System, San Diego, CA, USA;1. Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA;2. Department of Electrical Engineering and Computer Sciences, UC Berkeley, Berkeley, CA, USA;3. GE Healthcare, Fremont, CA, USA;4. Department of Electrical Engineering, Stanford University, Stanford, CA, USA;1. Technical University of Denmark, Department of Electrical Engineering, Kgs. Lyngby, Denmark;2. GE Healthcare, Park Alle 295, Broendby, Denmark;1. GE Healthcare, Toronto, ON, Canada;2. Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada;3. Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada;1. MR Research Centre, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark;2. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Aarhus, Denmark;3. The Technical University of Denmark, Department of Electrical Engineering, Kgs Lyngby, Denmark;4. GE Healthcare, Brøndby, Denmark;5. School of Mathematical Sciences, University College Dublin, Belfield, Dublin, Ireland |
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| Abstract: | In early stages of tendon disease, mechanical properties may become altered prior to changes in morphological anatomy. Ultrashort echo time (UTE) magnetic resonance imaging (MRI) can be used to directly detect signal from tissues with very short T2 values, including unique viscoelastic tissues such as tendons. The purpose of this study was to use UTE sequences to measure T21, T1 and magnetization transfer ratio (MTR) variations of tendon samples under static tensile loads. Six human peroneal tendons were imaged before and under static loading using UTE sequences on a clinical 3 T MRI scanner. Tendons were divided into two static tensile loading groups: group A that underwent one-step loading (15 N) and group B that underwent two-step loading (15 and 30 N). The T21, T1 and MTR variations were investigated in two selected section regions of interest (ROIs), including whole and core sections. Mean T21 values for the first step of loading (groups A and B) in both whole section and core section ROIs were significantly decreased by 13 ± 7% (P = 0.028) and 16 ± 5% (P = 0.017), respectively. For the second loading step (group B), there was a consistent, but non-significant reduction in T21 value by 9 ± 2% (P = 0.059) and 7 ± 5% (P = 0.121) for whole and core sections, respectively. Mean T1 did not show any consistent changes for either loading steps (P > 0.05). Mean MTR increased slightly, but not significantly for both loading steps (P > 0.05). Significant differences were found only in T21 values of tendons by static tensile load application. Therefore, T21 monitoring during loading is suggested for quantitative investigation of the tendons biomechanics. |
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| Keywords: | Tendon Tensile loading MRI Ultrashort TE |
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