Visualisation studies and glomerular filtration in early diabetic rats |
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| Affiliation: | 1. University and Hospital Trust, Pathology, Department of Diagnostics and Pathology, 37134, Verona, Italy;2. Queen Elizabeth Hospital Birmingham, Pathology, Department of Histopathology, B152GW, Birmingham, UK;3. University and Hospital Trust, Division of General and Hepatobiliary Surgery, Department of Surgical Science, 37134, Verona, Italy;4. University and Hospital Trust, Kidney Transplant Center, Department of Surgical Science, 37126, Verona, Italy;5. University and Hospital Trust, Department CED, 37134, Verona, Italy;6. University and Hospital Trust, Neurosurgery and Intensive Care Unit, Department of Surgical Science, 37126, Verona, Italy |
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| Abstract: | The purpose of this mini-review is to show that more modern multi-photon microscopy approaches allow quantitative glomerular filtration experiments. Modern science has now entered a transition period from light microscopy to multi-photon confocal microscopy. Since the late 20th century, multi-photon microscopy has been applied in the study of organ function. In keeping with observations made in renal physiology and other representative studies throughout this transition period, and in the context of advancing microscopy techniques, this review has been presented as a comment on the glomerular filtration barrier, with a focus on the early aetiopathogenesis of diabetes. |
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| Keywords: | Visualisation In-vivo Kidney Multi-photon microscopy Microcirculation Glomerular filtration |
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