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Protein tyrosine phosphatase 1B inhibitors as antidiabetic agents – A brief review
Institution:1. Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Baghpat By-pass Crossing, NH-58, Delhi-Haridwar Highway, Meerut 250005, India;2. Department of Chemistry, Indian Institute of Chemical Biology (CSIR), 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, W.B., India;1. School of Pharmacy, Yancheng Teachers’ University, Yancheng, Jiangsu 224051, People’s Republic of China;2. Laboratory of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People’s Republic of China;1. School of Life Science, Biotechnology, Dalian University of Technology, Dalian, Liaoning 116024, China;2. New Drug Research and Development Center, North China Pharmaceutical Group Corporation and National Microbial Medicine Engineering and Research Center, Shijiazhuang, Hebei 050015, China;3. School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China;1. Department of Chemistry, University of Lucknow, Lucknow 226007, Uttar Pradesh, India;2. ‘Hygeia’, Center of Excellences in Pharmaceutical Sciences (CEPS), Guru Govind Singh Indraprastha University, Sec 16-C, Dwarka, New Delhi 110078, India;1. Center for Neuroscience and Cell Biology, University of Coimbra, Portugal;2. Institute for Interdisciplinary Research, University of Coimbra, Portugal;3. Department of Geriatrics, and Arkansas Children''s Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
Abstract:Diabetes mellitus and obesity are one of the most common health issues spread throughout world and raised the medical attention to find the new effective agents to treat these disease state. Occurrence of the drug resistance to the insulin and leptin receptor is also challenging major issues. The molecules that can overcome this resistance problem could be effective for the treatment of both type II diabetes and obesity. Protein Tyrosine Phosphatase (PTP) has emerged as new promising targets for therapeutic purpose in recent years. Protein Tyrosine Phosphatase 1B (PTP 1B) act as a negative regulator of insulin and leptin receptor signalling pathways. Several approaches have been successfully applied to find out potent and selective inhibitors. This article reviews PTP 1B inhibitors; natural, synthetic and semi-synthetic that showed inhibition towards enzyme as a major target for the management of type II diabetes. These studies could be contributing the future development of PTP 1B inhibitors as drugs.
Keywords:Antidiabetic  Diabetes  Inhibitors  Insulin  Phosphatase  PTP 1B
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