Synthesis,characterization and biological studies of Schiff bases derived from heterocyclic moiety |
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| Institution: | 1. Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 22, Kerala, India;2. Department of Chemistry, M.G. College, Trivandrum, Kerala, India;1. Department of Mathematics, Science & Humanities, Shroff S. R. Rotary Institute of Chemical Technology, Valia 393 135, India;2. Organic Research Laboratory, Department of Bioresources and Food Science, College of Life and Environmental Sciences, Konkuk University, Seoul 143 701, Republic of Korea;3. College of Life Science and Biotechnology, Department of Biological and Environmental Science, Dongguk University, 32, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-820, Republic of Korea;4. Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-820, Republic of Korea;1. Department of Chemistry, Mar Ivanios College (Autonomous), Nalanchira, Thiruvananthapuram, 695015, Kerala, India;2. Department of Glass Processing, FunGlass, Alexander Dub?ek University of Tren?ín, Tren?ín, Slovakia;3. Centre for Molecular & Biophysics Research, Department of Physics, Mar Ivanios College (Autonomous), Nalanchira, Thiruvananthapuram, 695015, Kerala, India;1. Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;2. Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA;1. Department of Science and Mathematics Engineering, Faculty of Petroleum and Mining Engineering, Suez University, Suez, Egypt;2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt;3. Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt |
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| Abstract: | Some new Schiff bases (H1-H7) have been synthesized by the condensation of 2-aminophenol, 2-amino-4-nitrophenol, 2-amino-4-methylphenol, 2-amino benzimidazole with thiophene-2-carboxaldehyde and pyrrole-2-carboxaldehyde. The structures of newly synthesized compounds were characterized by elemental analysis, FT-IR, 1 H NMR, UV–VIS, and single crystal X-ray crystallography. The in vitro antibacterial activity of the synthesized compounds has been tested against Salmonella typhi, Bacillus coagulans, Bacillus pumills, Escherichia coli, Bacillus circulans, Pseudomonas, Clostridium and Klebsilla pneumonia by disk diffusion method. The quantitative antimicrobial activity of the test compounds was evaluated using Resazurin based Microtiter Dilution Assay. Ampicillin was used as standard antibiotics. Schiff bases individually exhibited varying degrees of inhibitory effects on the growth of the tested bacterial species. The antioxidant activity of the synthesized compounds was determined by the 1,1-diphenyl-2-picrylhydrazyl(DPPH) method. IC50 value of synthesized Schiff bases were calculated and compared with standard BHA. |
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| Keywords: | Schiff bases Heterocyclic aldehydes Amines Spectral studies Antibacterial activity Antioxidant activity |
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