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Mismatch repair and homeologous recombination
Institution:1. Department of Genetics, Cancer Genomics Netherlands, Erasmus MC, Rotterdam, The Netherlands;2. Department of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands;1. Institute of Biochemistry, ETH Zürich, Otto-Stern-Weg 3, 8093 Zürich, Switzerland;2. Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Bellinzona, 6500, Switzerland;3. Peter Debye Institute for Soft Matter Physics, Universität Leipzig, Leipzig 04103, Germany;1. Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA 92093-0669, USA;2. Departments of Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0669, USA;3. Departments of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0669, USA;4. Moores – UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0669, USA;5. Institute of Genomic Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0669, USA;1. Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA 95616-8665, USA;2. Department of Molecular & Cellular Biology, University of California, Davis, Davis, CA 95616-8665, USA
Abstract:DNA mismatch repair influences the outcome of recombination events between diverging DNA sequences. Here we discuss how mismatch repair proteins are active in different homologous recombination subpathways and specific reaction steps, resulting in differential modulation of these recombination events, with a focus on the mechanism of heteroduplex rejection during the inhibition of recombination between slightly diverged (homeologous) DNA sequences.
Keywords:Mismatch repair  Homologous recombination  Homeologous recombination  Antirecombination  Heteroduplex rejection
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