1. Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan;2. College of Medicine, Chang Gung University, Taoyuan 333, Taiwan;3. Department of Orthopaedic, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Abstract:
Gene therapy has converged with bone engineering over the past decade, by which a variety of therapeutic genes have been delivered to stimulate bone repair. These genes can be administered via in vivo or ex vivo approach using either viral or nonviral vectors. This article reviews the fundamental aspects and recent progresses in the gene therapy-based bone engineering, with emphasis on the new genes, viral vectors and gene delivery approaches.
