Backbone assignment of human proliferating cell nuclear antigen期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Backbone assignment of human proliferating cell nuclear antigen

Authors:	Ricardo Sánchez Daniel Torres Jesús Prieto Francisco J. Blanco Ramón Campos-Olivas

Affiliation:	(1) Structural and Computational Biology Programme, Spanish National Cancer Center (CNIO), C. Melchor Fernández Almagro 3, Madrid, 28029, Spain;(2) Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio, 48160, Spain

Abstract:	PCNA is an essential factor for DNA replication, repair, chromatin metabolism, and effector of cell-cycle regulatory signals. The assignment of backbone ¹H_N, ¹³C_α, ¹³CO, and ¹⁵N, and sidechain ¹³C_β resonances of the human PCNA homotrimeric ring (∼90 kDa, 261 residues) is reported here.

Keywords:	Sliding clamp PCNA DNA metabolism TROSY Deuterated protein
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