| Affiliation: | (1) MRC Centre for Developmental Neurobiology, King's College London, SE1 1UL, 4thFloor,New Hunt's House, Guy's Campus, London, UK;(2) Department of Anatomy, University of California, San Francisco, Mission Bay, 94143 - 2822, 19B,Genetics Dev 448-F, San Francisco, CA, USA |
| Abstract: | Background Cerebellar granule cell precursors are specifically generated within the hindbrain segment, rhombomere 1, which is bounded rostrally by the midbrain/hindbrain isthmus and caudally by the boundary of the Hoxa2 expression domain. While graded signals from the isthmus have a demonstrable patterning role within this region, the significance of segmental identity for neuronal specification within rhombomere 1 is unexplored. We examined the response of granule cell precursors to the overexpression of Hoxa2, which normally determines patterns of development specific to the hindbrain. How much does the development of the cerebellum, a midbrain/hindbrain structure, reflect its neuromeric origin as a hindbrain segment? |
