Effect of chronic heat exposure on in-vitro drug metabolism in the rat

The $\text{in-vitro}$ rate of drug metabolizing enzymes was investigated in chronically heat exposed male rats. Exposure to 35±2°C for 30 days resulted in significant reduction in the rates of both hepatic N-demethylation of parachloro-N-methylaniline and aniline hydroxylation. Substantial elevation of rectal temperature and marked reduction in body and liver weights was observed in the same rats. The significance of these results is discussed.