Naloxone reduction of stress-related feeding |
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Authors: | Martin T Lowy Roger P Maikel George KW Yim |
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Institution: | Department of Pharmacology & Toxicology, School of Pharmacy & Pharmacal Sciences Purdue University, West Lafayette, Indiana 47907, USA |
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Abstract: | The effects of the narcotic antagonist, naloxone, on various types of stress- related feeding in rats were examined. Tail pinch-induced eating of a palatable substance, and 3 hr daytime rat chow intake following acute 2-deoxy-D-glucose (2-DG, 400 mg/kg) administration or 24 hr food deprivation were significantly decreased by low doses (1 mg/kg) of naloxone. Night time food intake was likewise decreased by naloxone (4 mg/kg). In contrast, hyperphagia induced by insulin (10 U/kg) was not decreased by naloxone (0.06–16 mg/kg). These findings suggest that narcotic antagonists should be considered as possible anorexics selective for stress-induced eating, and that endogenous opiates may prove to be another significant factor involved in the control of food intake. |
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Keywords: | To whom reprint requests should be addressed |
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