I. A unique deaminated metabolite of sulfamethazine [4-amino-N-(4, 6-dimethyl-2-pyrimidinyl) benezenesulfonamide] in swine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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I. A unique deaminated metabolite of sulfamethazine [4-amino-N-(4, 6-dimethyl-2-pyrimidinyl) benezenesulfonamide] in swine

Authors:	G Paulson C Struble

Institution:	1. Metabolism and Radiation Research Laboratory Agricultural Research Science and Education Administration U. S. Department of Agriculture Fargo, ND 58105, USA;2. Animal Science Department North Dakota State University Fargo, ND 58105, USA

Abstract:	¹⁴C-Sulfamethazine 4-amino- $N$ -(4, 6-dimethyl-2-pyrimidinyl)- ¹⁴C-benzenesulfonamide] was administered orally to young, 21-kg male swine. A unique metabolite, $N$ -(4, 6-dimethyl-2-pyrimidinyl)- ¹⁴C-benzenesulfonamide (¹⁴C-desaminosulfamethazine), was identified in skeletal muscle collected 24 hr after dosing. The structure of the metabolite was confirmed by synthesis, comparative electron impact mass spectrometry, chemical ionization mass spectrometry, and infrared spectroscopy.

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