Valproic acid is associated with cognitive decline in HIV-infected individuals: a clinical observational study |
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| Authors: | Lucette A Cysique Paul Maruff Bruce J Brew |
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| Affiliation: | (1) Department of Psychiatry, University of California at San Diego, San Diego, California, USA;(2) Centre for Neuroscience, University of Melbourne, Melbourne, Australia;(3) Departments of Neurology and HIV Medicine, St Vincent's Hospital, Sydney, Australia |
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| Abstract: | Background Valproic acid (VPA) is often used to control pain in HIV-related neuropathy. However, the effect of VPA on cognitive functions in advanced HIV-infected individuals is largely unknown. A recent study would suggest that it may have a neuroprotective effect, the doses used were low and the observation period short. |
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