绿脓杆菌MSHA菌毛株菌苗对反复发作性尿路感染的治疗及其机制研究

采用绿脓杆菌ＭＳＨＡ菌毛株菌苗（ＰＡ－ＭＳＨＡ菌苗）治疗了４０例使用抗生素无效的ＲＵＴＩ，取得了满意的疗效，有效率９５％（３８／４０），治愈率９２．５％（３７／４０）。对其中１８例进行了治疗前后血清抗ＭＳＨＡ菌毛株抗体效价和外周血Ｔ淋巴细胞亚群测定。疗后患者血清中抗ＭＳＨＡ菌毛株抗体效价较疗前增高８～６４倍；同时外周血Ｔ淋巴细胞亚群的比例得到了改善，ＣＤ３＾＋和ＣＤ４＾＋Ｔ细胞的百分率显著提高（Ｐ〈０．０１），而ＣＤ８＾＋Ｔ细胞的百分率则显著下降（Ｐ〈０．００１）。治疗过程未见明显的副作用。研究表明：ＰＡ－ＭＳＨＡ菌苗对反复发作性尿路感染治愈率高，安全可靠，患者的免疫低下状态得到改善，且对多种病原菌（包括革兰阴性杆菌及其Ｌ型、金黄色葡萄球菌及其Ｌ型）所致的ＲＵＴＩ效果都很好。

STUDIES ON MECHANISM OF IMMUNIZATION AGAINST RECURRENT URINARY TRACT INFECTION WITH MSHA-PILIATED STRAIN VACCINE OF SEUDOMONAS AERUGINOS

Used the MSHA-piliated strain vaccine of Pseudomonal auroginosa (PA-MSHA vaccine) to treat 40 cases of RUTI with invalid antibiotic therapy, and gained satisfactory curative effects with effective rate 95 percent and cure rate 92.5 percent.Serum anti-MSHA piliated strain antibody and peripheral blood T lymphocyte subsets were measured in 18 of the patients.The posttherapy antibody titers increased as great as 8 to64 times that of pretherapy.After the vaccine therapy,the CD 3 and CD 4 percentage were significantly increased ( P <0.001),whereas the CD 8 percentage was significantly decreased ( P <0.001).During the treatment,no side effect was found.This study confirms that the PA-MSHA vaccine:(1)it is highly curative against RUTI caused by various pathogens(G-bacilli and their L forms,Staphylococci aureus and their L forms);(2)it is safe and reliable;(3)it can improve immune state of the patients.