血清DCN、NRG-1、MIF水平与首发未服药精神分裂症患者临床症状和认知功能的相关性分析

目的:探讨血清核心蛋白多糖(DCN)、神经调节蛋白-1(NRG-1)、巨噬细胞迁移抑制因子(MIF)水平与首发未服药精神分裂症患者临床症状和认知功能的相关性。方法:选择2018年1月~2020年11月期间长江大学附属第一医院收治的首发未服药精神分裂症患者80例作为精神分裂症组,同期于长江大学附属第一医院进行体检的健康志愿者80例作为对照组。应用阳性和阴性症状量表(PANSS)评估患者精神病理症状,应用MATRICS共识认知成套测验(MCCB)评估所有受试者认知功能。根据PANSS评分将精神分裂症组分为PANSS评分高分组和低分组,比较两组血清DCN、NRG-1、MIF水平,并分析以上指标水平与PANSS总分、MCCB各项评分的相关性。结果:精神分裂症组患者PANSS总分为(77.18±13.57)分。精神分裂症组MCCB各项评分均低于对照组(P<0.05)。精神分裂症组血清DCN、NRG-1水平低于对照组,MIF水平高于对照组(P<0.05)。PANSS高分组血清DCN、NRG-1水平低于PANSS低分组,MIF水平高于PANSS低分组(P<0.05)。Pearson相关性分析显示,首发未服药精神分裂症患者血清DCN、NRG-1水平与PANSS总分呈负相关,与MCCB各项评分呈正相关,MIF水平与PANSS总分呈正相关,与MCCB各项评分呈负相关(均P<0.05)。结论:首发未服药精神分裂症患者血清DCN、NRG-1、MIF水平异常,且以上指标水平与患者临床症状和认知功能受损有一定联系,提示检测以上指标水平可能为该病患者认知功能及临床症状的评估提供参考。

Correlation Analysis of Serum Levels of DCN, NRG-1 and Macrophage MIF with Clinical Symptoms and Cognitive Function in First-episode Schizophrenic Patients without Medication

ABSTRACT Objective: To investigate the correlation between the serum levels of Decorin (DCN), neuroregulatory protein-1 (NRG-1) and macrophage migration inhibitory factor (MIF) and the clinical symptoms and cognitive function of first-episode schizophrenic patients without medication. Methods: 80 first-episode schizophrenic patients without medication in The First Affiliated Hospital of Changjiang University from January 2018 to November 2020 were selected as the schizophrenia group, and at the same time in The First Affiliated Hospital of Changjiang University for physical examination of 80 healthy volunteers as the control group. The positive and negative symptom scale (PANSS) was used to evaluate the psychopathological symptoms of the patients, and the cognitive function of all subjects was evaluated by the MATRICS consensus cognitive battery (MCCB). According to the PANSS score, the schizophrenia group was divided into PANSS score high score group and low score group. The serum levels of DCN, NRG-1 and MIF were compared between the two groups, and the correlation between the above indexes and PANSS total score and MCCB scores were analyzed. Results: The PANSS total score in schizophrenia group was (77.18±13.57) score. The scores of MCCB in schizophrenia group were lower than those in control group (P<0.05). The levels of serum DCN and NRG-1 in schizophrenia group were lower than those in control group, and MIF was higher than that in control group (P<0.05). The levels of serum DCN and NRG-1 in PANSS high score group were lower than those in PANSS low score group, and MIF was higher than that in PANSS low score group (P<0.05). Pearson correlation analysis showed that the serum levels of DCN and NRG-1 were negatively correlated with PANSS total score in patients with first-episode untreated schizophrenia, and positively correlated with the MCCB scores, and the levels of MIF was positively correlated with the PANSS total score, and negatively correlated with the MCCB scores (all P<0.05). Conclusion: There are abnormal levels of serum DCN, NRG-1 and MIF in first-episode schizophrenic patients without medication, and the levels of these indexes are correlated with clinical symptoms and cognitive impairment, suggesting that the detection of these indexes may provide a reference for the evaluation of cognitive function and clinical symptoms in patients with this disease.