妊娠组织中CD146和HGF的表达与稽留流产的相关性分析

目的:分析妊娠组织中CD146和肝细胞生长因子(Hepatocyte growth factor,HGF)的表达与稽留流产的相关性,探讨CD146、HGF在妊娠早期的潜在作用,为早期预防稽留流产的发生提供新的思路。方法:收集2019年7月至2019年12月于我院门诊行人工流产的病例,选取妊娠时间59周,年龄1835岁,近三个月未服用激素类药物,且无子宫肌瘤、子宫内膜病变、全身免疫性疾病、内分泌疾病的病例,分为稽留流产组40例;正常妊娠组50例。分析两组资料的差异性,通过免疫组化法检测两组蜕膜组织中CD146和HGF的表达情况并分析CD146和HGF的异常表达与稽留流产是否具有相关性。结果:CD146和HGF在稽留流产组和正常早孕组蜕膜组织中均有表达;稽留流产组蜕膜组织中CD146、HGF的表达均较正常妊娠组显著降低(P<0.05);CD146和HGF的表达呈正相关性(r>0,P<0.05);CD146和HGF的异常表达与稽留流产具有相关性。结论:稽留流产患者蜕膜组织中CD146和HGF的表达均下降,可能与稽留流产的发生有关,但CD146和HGF的表达下调参与稽留流产的发生机制尚不十分明确,需进一步探讨。妊娠组织中CD146和HGF的表达可能具有正相关性。CD146和HGF可能作为稽留流产在母胎界面方向研究的新的靶点,二者在妊娠过程中可能具有正相关性,尚需实验进一步验证。

Correlation Analysis of CD146 and HGF with Missed Abortion

ABSTRACT Objective: To explore the potential role of CD146 and HGF in early pregnancy and provide new ideas for the early prevention of missed abortion by analyzing the correlation between the expression of CD146 and Hepatocyte growth factor (HGF) in pregnancy tissue and missed abortion. Methods: The cases of abortion in the outpatient department of Harbin Medical University from August 2019 to December 2019 were collected, and those who were 18-35 years old, menopause for 5 to 9 weeks, did not take any hormone drugs within three months, and had no histroy of uterus, fibroids, endometrial diseases, systemic immune diseases, endocrine diseases, were divided into 40 cases of miscarriage and 50 cases of normal pregnancy. The difference between the two groups of data was analyzed. The expression of CD146 and HGF in the decidual tissues of the two groups was detected by immunohistochemistry, and whether the abnormal expression of CD146 and HGF is related to missed abortion was analyzed. Results: CD146 and HGF are expressed in the decidual tissues of both the missed abortion group and the normal early pregnancy group. The expressions of CD146 and HGF in the decidual tissue of the missed abortion group were significantly lower than those of the normal pregnancy group (P<0.05). There was a positive correlation between the expression of CD146 and HGF in pregnancy tissues (r>0, P<0.05). The abnormal expressions of CD146 and HGF are correlated with missed abortion. Conclusion: The decreased expression of CD146 and HGF in decidual tissues of patients with missed abortion may be related to the occurrence of missed abortion. However, it is not clear how low-expression CD146 and HGF participate in the mechanism of missed abortion, and further research is needed. The expression of CD146 and HGF in pregnancy tissue may have a positive correlation. CD146 and HGF may become new targets for the study of missed abortion at the maternal-fetal interface. The correlation between the two during pregnancy needs further study.