血清P53、MMP-7抗体表达与食管癌的病理类型、分期的相关性

目的:探讨血清P53、基质金属蛋白酶-7(Matrix metalloproteinase-7,MMP-7)抗体表达与食管癌的病理类型、分期的相关性.方法:2019年10月-2020年4月选择在本院诊治的食管癌患者80例作为食管癌组,同期选择体检的健康人50例作为对照组,检测两组血清P53、MMP-7抗体表达情况,调查...

Correlation of Serum P53, MMP-7 antibody Expression with Pathological Type, Stage of Esophageal Cancer

ABSTRACT Objective: To investigate the correlation between serum P53, Matrix metalloproteinase-7 (MMP-7) antibody expression and the pathological type, stage of esophageal cancer. Methods: A total of 80 patients with esophageal cancer,who were diagnosed and treated in Huai''an Second People''s Hospital from October 2019 to April 2020, were chosen as esophageal cancer group; 50 healthy people with physical examination were chosen as control group during the same period. The expression of serum P53 and MMP-7 antibody was detected in the two groups. The clinicopathological data of the patients were investigated and were performed a correlation analysis. Results: The serum P53 and MMP-7 antibody titers and positive rates of the esophageal cancer group were significantly higher than those of the control group, and the differences were statistically significant (P<0.05). In the esophageal cancer group, the differences in P53, MMP-7 antibody titers and positive expression rates among the patients with different clinical stages, tissue differentiation, lymph node metastasis, tumor size were statistically significant (P<0.05). Spearman rank correlation test analysis showed that the expression of P53 and MMP-7 antibodies were correlated with the clinical stage, and were not correlated with the clinical pathological type (P<0.05). Cox multivariate analysis showed that clinical stage, tissue differentiation, lymph node metastasis, and tumor size were the main factors affected the expression of serum P53 and MMP-7 antibodies (P<0.05). P53 and MMP-7 antibody indexes were analyzed by ROC curve. The area under the P53 curve was 0.804, with a sensitivity of 90.0% and a specificity of 60.0%. The area under the MMP-7 curve was 0.835, with a sensitivity of 97.2% and a specificity of 62.5%. Conclusion: Serum P53 and MMP-7 are highly expressed in the patients with esophageal cancer, which are correlated with the clinical stage of the patients, but not correlated with the clinical pathological type. The clinical stage, tissue differentiation, lymph node metastasis, and tumor size are the main factors affected the expression of serum P53 and MMP-7 antibodies, and both have high diagnostic sensitivity.