外泌体在淋巴瘤中的研究进展

摘要：病毒感染和环境污染等使得淋巴瘤的发病率逐年升高，早期诊断和精准治疗具有十分重要的临床意义。外泌体是一种脂质双层膜结构的微小囊泡，介导了细胞间交流和信息交换。近几年许多研究证实外泌体是淋巴瘤的发生、进展和耐药的重要机制。外泌体内核酸和小分子可用于淋巴瘤的早期诊断和预测患者预后。材料学修饰可显著增强外泌体治疗的靶向性和治疗效能。本文总结了外泌体生物学特性、分离和鉴定方法、与肿瘤相关性、及其在淋巴瘤中的研究进展，为淋巴瘤的预警和治疗提供参考。

Research Progress of Exosomes in Lymphoma

ABSTRACT: Viral infection and environmental pollution make the incidence of lymphoma increase year by year. Early diagnosis and precise treatment are of great clinical significance. Exosomes are tiny vesicles of lipid bilayer membrane structure, which mediate cell to cell communication and information exchange. In recent years, many studies have proved that exosomes are the important mechanism of the occurrence, development and drug resistance of lymphoma. Nucleic acids and small molecules in exosomes can be used for early diagnosis and prognosis of lymphoma. Material modification can significantly enhance the targeting and therapeutic efficacy of exosomes. This paper summarized the biological characteristics of exosomes, the methods of isolation and identification, the relationship between exosomes and tumor, and the research progress of exosomes in lymphoma, to provide references for the early warning and treatment of lymphoma.