玉屏风颗粒联合西咪替丁对过敏性紫癜患儿临床疗效及外周血免疫学指标的影响

目的:探讨玉屏风颗粒联合西咪替丁对过敏性紫癜患儿临床疗效及外周血免疫学指标的影响。方法:选取2017年1月至2019年12月我院68例过敏性紫癜患儿为研究对象,根据随机化原则将受试儿进行分组,其中对照组34例患儿仅接受西咪替丁治疗,研究组45例患儿在对照组的基础上口服玉屏风颗粒治疗,比较两组的治疗效果、治疗前后外周血免疫学指标水平变化及用药安全性。结果:研究组临床治疗总有效率显著高于对照组(P<0.05),治疗前两组各免疫学指标及各炎性因子水平比较无统计学差异(P>0.05),治疗后两组各免疫学指标及各炎性因子水平较治疗前均明显降低,且研究组显著低于对照组(P<0.05),两组治疗期间不良反应发生率无差异(P>0.05)。结论:玉屏风颗粒联合西咪替丁可有效改善患儿的临床症状及外周血免疫学指标,疗效安全显著,值得在过敏性紫癜患儿治疗中应用及推广。

Effect of Yupingfeng Granules Combined with Cimetidine on Clinical Efficacy and Peripheral Blood Immunological Parameters in Children with Allergic Purpura

ABSTRACT Objective: To explore effect of Yupingfeng granules combined with cimetidine on clinical efficacy and peripheral blood immunological parameters in children with allergic purpura. Methods: 68 children with allergic purpura were selected as the subjects and conducted retrospective study from January 2017 to December 2019. The subjects were grouped according to the principle of randomization, the control group of 34 cases were treated with cimetidine, the study group of 34 cases on the basis of this combination of Yupingfeng granules. Therapeutic effect, changes in peripheral blood immunological indicators before and after treatment, and medication safety were compared the two groups. Results: The total effective rate of clinical treatment in the study group was significantly higher than that in the control group(P<0.05). There were no significant differences in immunological indexes and inflammatory factors levels between the two groups before treatment(P>0.05). After treatment, the immunological indexes and inflammatory factors levels of the two groups were significantly lower than those before treatment, and the study group was significantly lower than the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Yupingfeng granules combined with cimetidinecan effectively improve the clinical symptoms and peripheral blood immunological indicators, and the effect is safe and significant. It is worthy of application and promotion in the treatment of children with allergic purpura.