肺炎支原体感染对儿童血常规参数及C反应蛋白水平的影响

摘要 目的：探讨肺炎支原体（Mycoplasma pneumoniae, MP）感染对儿童血常规数及C反应蛋白（C reactive protein, CRP）水平的影响。方法：以60例肺炎支原体抗体（MP-IgM）阳性患儿作为观察组，选取同期60名MP-IgM阴性儿童作为对照组，对两组患儿血常规参数和CRP水平进行回顾性分析。结果：与对照组比较，观察组红细胞压积、血红蛋白、单核细胞比例、单核细胞计数、中性粒细胞比例、中性粒细胞计数、红细胞计数均数或中位数升高，嗜碱性粒细胞比例、嗜碱性粒细胞计数、嗜酸性粒细胞比例、嗜酸性粒细胞计数、淋巴细胞比例（LY）、淋巴细胞比计数（LY#）、平均红细胞血红蛋白量、红细胞平均体积、平均血小板体积、血小板压积、血小板分布宽度、血小板计数、红细胞分布宽度均数或中位数降低；观察组患儿的CRP水平中位数显著高于对照组，以上差异有统计学意义（P<0.05）；Logistic多元回归分析结果显示，MP感染与淋巴细胞比例、淋巴细胞比计数降低具有正相关性（P<0.05）。结论：MP感染患儿的血常规参数和CRP水平均发生变化，临床医生应对这些参数给予关注和连续监测，从而提高诊疗效果。

Mycoplasma Pneumoniae Infections on Blood Routine Index and C-reactive Protein Levels in Children

ABSTRACT Objective: To analyze the influences of Mycoplasma pneumoniae (MP) infections on blood routine indexes and C-reactive protein (CRP) level in children. Methods: The 60 children with positive Mycoplasma hyopneumoniae antibody (MP-IgM) were enrolled as the observation group and 60 children with negative MP-IgM were selected as the control group. The blood routine indexes and CRP levels between the two groups were analyzed retrospectively. Results: Compared with those in the control group, the levels of medians of hematocrit, hemoglobin, proportion of monocytes, monocyte count, proportion of neutrophils, neutrophil count, red blood cell count and the decreasing means or medians of proportion of basophils, basophils count, proportion of eosinophils, eosinophils count, proportion of lymphocytes (LY), lymphocytes count (LY#), average hemoglobin content of red blood cells, average volume of red blood cells, average volume of platelets, the hematocrit of platelets, distribution width of platelets, platelets count, distribution width of red blood cells increased in the observation group with significant difference (P<0.05); and the level of CRP of the children in the observation group was higher than that in the control group (P<0.05). The results of Logistic multiple regression analysis showed that MP infection was correlated with the decrease of LY and LY# (P < 0.05). Conclusion: The changes of blood routine indexes and CRP level in children with MP infection are complicated with certain characteristics. The clinicians should pay attention to these indexes and monitor them continuously, so as to improve the clinical diagnosis and treatment effects which benefit to improve the prognosis of patients.