首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Structure and synthesis of malformin A1
Authors:Miklos Bodanszky  Glenn L Stahl
Institution:Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 USA
Abstract:The structure of malformin A1, a metabolic product of Aspergillus niger, was reexamined and the sequence of its amino acid constituents established as
/></figure>The cyclopentapeptide-disulfide corresponding to this structure was prepared through stepwise synthesis of the protected pentapeptide derivative, benzyloxy-carbonyl-l-isoleucyl-<em>S</em>-benzyl-d-cysteinyl-<em>S</em>-benzyl-d-cysteinyl-l-valyl-d-leucine methylester, which in turn was converted to the hydrazide, partially deprotected, and cyclized via the azide. On removal of the S-benzyl groups and oxidation to the disulfide, a synthetic material was obtained that was indistinguishable from natural malformin A<sub>1</sub> and was as equally potent in causing curvatures on corn roots.</td>
	  </tr> 
	  <tr>
	   <td align=
Keywords:Author to whom correspondence should be addressed  
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号