Association study of folate-related enzymes (MTHFR,MTR, MTRR) genetic
variants with non-obstructive male infertility in a Polish population |
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| Authors: | Mateusz Kurzawski Anna Wajda Damian Malinowski Anna Kazienko Rafal Kurzawa Marek Drozdzik |
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| Affiliation: | 1.Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.;2.Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland.;3.Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin, Poland. |
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| Abstract: | Spermatogenesis is a process where an important contribution of genes involved infolate-mediated one-carbon metabolism is observed. The aim of the present study wasto investigate the association between male infertility and theMTHFR (677C > T; 1298A > C), MTR (2756A> G) and MTRR (66A > G) polymorphisms in a Polish population.No significant differences in genotype or allele frequencies were detected betweenthe groups of 284 infertile men and of 352 fertile controls. These resultsdemonstrate that common polymorphisms in folate pathway genes are not major riskfactors for non-obstructive male infertility in the Polish population. |
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| Keywords: | MTHFR MTR MTRR polymorphism infertility |
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