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| TFF2在胃癌中的表达及与幽门螺杆菌感染关系的研究 | |
| 引用本文： | 荣芳,王勇,王满贵,侯恒. TFF2在胃癌中的表达及与幽门螺杆菌感染关系的研究[J]. 中国微生态学杂志, 2011, 23(4): 293-297 |
| 作者姓名： | 荣芳 王勇 王满贵 侯恒 |
| 作者单位： | 1. 大同大学医学院内科教研室,山西,大同,037008 2. 大同市第五人民医院,山西,大同,037000 3. 大同大学医学院,山西,大同,037008 |
| 基金项目： | 山西省回国留学人员科研资助项目 |
| 摘 要： | 目的探讨三叶因子Ⅱ(Trefoil factors2,TFF2)在胃癌和癌前病变中的表达及与幽门螺杆菌感染(Helicobacter pylori,H.pylori)的关系。方法选取经病理证实的慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌4种不同胃黏膜病变的标本140例,用免疫组化法检测标本中TFF2的表达及H.pylori的感染情况,并分析TFF2的表达与H.pylori的感染的关系。结果在慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌中,TFF2和H.pylori的表达率依序呈逐渐增加的趋势,但TFF2在胃癌组织中表达降低。H.pylori阳性组TFF2的表达率低于阴性组,TFF2的阳性率与H.pylori感染率之间呈负相关(r=-0.335,P<0.05)。结论 TFF2的表达和H.pylori的感染与肿瘤的发生密切相关,检测该指标可为胃癌诊断、判断预后和指导治疗提供理论依据。 |
| 关 键 词： | 三叶因子Ⅱ 幽门螺杆菌 胃癌 |
The expression of TFF2 in gastric cancer and its correlation with the infection of Helicobacter pylori |
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| RONG Fang,WANG Yong,WANG Man-gui,HOU Heng. The expression of TFF2 in gastric cancer and its correlation with the infection of Helicobacter pylori[J]. Chinese Journal of Microecology, 2011, 23(4): 293-297 | |
| Authors: | RONG Fang WANG Yong WANG Man-gui HOU Heng |
| Affiliation: | 1.Department of Medicine,Medical College of Datong University,Datong 037008,China;2.The Fifth People′s Hospital of Datong City,Datong 037000,China;3.Medical College of Datong University,Datong 037008,China) |
| Abstract: | Objective To investigate the expression of Trefoil factors2(TFF2) in gastric cancer and precancerous condition and its correlation with the infection of Helicobacter pylori(H.pylori).Method The expressions of TFF2 and the infection of H.pylori were studied by immunohistochemical methods in 140 gastric specimens including 25 chronic superficial gastritis(CSG),30 gastric ulcer(GU),35 chronic atrophic gastritis(CAG) and 50 gastric cancers(GC).The statistic software was used to analyze the expression of TFF2 in... |
| Keywords: | Trefoil factors2 Helicobacter pylori Gastric cancers |
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