噻托溴铵治疗老年稳定期COPD 临床观察

目的:探讨噻托溴铵吸入剂对老年吸烟稳定期慢性阻塞性肺疾病(COPD)的临床疗效。方法:入选稳定期COPD老年患者92例,随机分为2组各46例,观察组予噻托溴铵吸入剂18微克每日一次,对照组予缓释茶碱0.1克每12小时口服,两组均按需使用沙丁胺醇气雾剂,随访2月,比较两组治疗前后的肺功能与生活质量改善情况。结果:观察组治疗后St George评分明显下降(P<0.01),显著低于对照组(P<0.01),FEV1/FVC、FEV1/Pred、FEV1均较治疗前明显升高(P<0.01),而对照组治疗前后无显著差异(P>0.05)。结论:吸入噻托溴铵能显著改善老年吸烟COPD稳定期患者的肺功能与生活质量。

Clinical Observation on Tiotropium Treatment of Elderly Patients with Stable COPD

Objective: To investigate the efficacy of tiotropium inhaler in elderly smokers with stable chronic obstructive pulmonary disease(COPD).Methods: 92 elderly patients with stable COPD were randomly divided into 2 groups with each of 46 cases.The observation group were treated with inhaled tiotropium 18 micrograms once daily,and the control group were treated with sustained-release theophylline 0.1 g orally every 12 hours.All patients might use salbutamol aerosol if needed,and followed up for 2 months.Lung function and quality of life improvement were compared before and after treatment.Results: In the observation group,St George score decreased significantly after treatment(P<0.01),significantly lower than the control group(P<0.01).FEV1/FVC,FEV1/Pred,FEV1 was significantly higher than those before treatment(P<0.01).However,the control group showed no significant difference(P>0.05).Conclusion: Inhaled tiotropium can significantly improve lung function and life quality of elderly smokers with stable COPD.