EphrinB2/EphB4 在血管生长中的作用及中医药研究展望*

近年来,有关ephrin及其Eph受体的作用研究已从神经系统方面逐步向血管生长扩展。已有研究表明ephrinB2/EphB4及其独特的双向信号转导几乎参与血管生长的每个方面,涉及血管发育过程中的动静脉分化、胚胎后血管新生包括内皮细胞增殖、迁移、粘附和分化等过程,且与VEGF、Notch等血管新生调控因子关系密切。另外,实验表明活血化瘀名方血府逐瘀汤显著的促血管新生作用与ephrinB2/EphB4相关,说明中医药促血管新生中ephrinB2/EphB4具有重要作用。本文部分总结了ephrinB2/EphB4在血管生长中的作用,并提出中医药在这方面的展望。

The Roles of EphrinB2/EphB4 in Vascular Growth and Traditional Chinese Medicine Angiogenesis Research

In recent years,the mechanism research of ephrins and their Eph receptors have been gradually expanded from nervous system to vascular growth.EphrinB2/EphB4 and their unique bi-directional signals mediated almost every stage of vascular growth including arterio-venous differentiation and postnatal angiogenesis which involved endothelial cells proliferation,migration,adhesion and differentiation.Their angiogenesis regulation mechanism had close relation to VEGF and Notch.In addition,experimental research have been demonstrated that the apparently angiogenic effects of Xuefu Zhuyu decoction can promote blood circulation and remove blood stasis,have some relation to ephrinB2/EphB4.That suggested ephrinB2/EphB4 could play important roles in angiogenesis induced by traditional Chinese medicine.Here we partly summarized how ephrinB2/EphB4 affected in vascular growth and prospected its work in traditional Chinese medicine research.