| SPARC 结构与功能研究进展 |
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| 引用本文： | 冯丹,蔡建,张颖一,傅强,王雅杰.SPARC 结构与功能研究进展[J].现代生物医学进展,2012,12(3):560-562. |
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| 作者姓名： | 冯丹 蔡建 张颖一 傅强 王雅杰 |
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| 作者单位： | 1. 第二军医大学附属长海医院肿瘤科 上海200433
2. 解放军第150医院普外科 河南洛阳471031 |
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| 基金项目： | 上海市重点学科资助项目(B905) |
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| 摘 要： | SPARC(secreted protein,acidic and rich in cysteine)是一种具有多样细胞生物学功能、分布广泛的分泌性基质蛋白。具有3个独立模块结构,不同肽段所行使生物学功能不尽相同。除破坏细胞粘附和抑制细胞周期进程外,SPARC还具有调节细胞分化、参与细胞对某些生长因子反应等生理功能。SPARC参与PI3K/AKT、MAPK、Wnt通路的调控,并对β-FGF、VEGF、PDGF、TGFβ等生长因子以及基质蛋白酶具有调节作用。对SPARC功能多样性的深入研究,有助于阐明SPARC组织特异性的作用机制。
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| 关 键 词： | SPARC 信号转导 生长因子 |
Progress of Structure and Function of SPARC |
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| FENG Dan,CAI Jian,ZHANG Ying-yi,FU Qiang,WANG Ya-jie.Progress of Structure and Function of SPARC[J].Progress in Modern Biomedicine,2012,12(3):560-562. |
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| Authors: | FENG Dan CAI Jian ZHANG Ying-yi FU Qiang WANG Ya-jie |
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| Institution: | 1(1 Department of Oncology,Changhai Hospital,Shanghai 200433,China; 2 Department of General Surgery,the 150th Central Hospital of Chinese PLA,Luoyang 471031,China) |
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| Abstract: | SPARC(secreted protein,acidic and rich in cysteine),a well-known secreted extracellular matrix-associated glycoprotein is known to be involved in multiple biological function.SPARC is widely distributed,consisted of three peptides with multi-function.Besides the roles in adhesion and cell cycle,SPARC also plays a role in cell differentiation and interacts with some growth factors.SPARC is involed in several signal pathways,such as PI3K/AKT,MAPK,Wnt.SPARC also can modulate several growth factors,such as β-FGF,VEGF,PDGF,TGFβ and MMPs.It can fully understand the specific mechanisms in different tissues through deepgoing studies of the functions of SPARC. |
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| Keywords: | SPARC Signal transduction Growth factors |
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