阻塞性睡眠呼吸暂停综合征与高血压临床关系分析

目的:研究阻塞性睡眠呼吸暂停综合征与高血压的临床关系及相关机制。方法:将258例鼾症患者分为三组:单纯鼾症对照组(N组)、单纯OSAHS组(O组)、OSAHS合并高血压组(O+H组)。对三组患者进行临床基础资料收集,ESS问卷调查及EP评分,多导睡眠监测及血压测定。结果:三组鼾症患者之间年龄、性别、吸烟、饮酒差异无统计学意义(P>0.05),OSAHS组及OSAHS+HT组体重指数及颈围明显高于单纯鼾症组,差异有统计学意义(P<0.05);与单纯鼾症组比较,OSAHS组及OSAHS+HT组的EP评分、AHI、LaSO2(%)、MSaO2、Ts90%差异明显有统计学意义(P<0.05);与对照组相比OSAHS组及OSAHS+HT组睡眠前后收缩压和舒张压升高,差异有统计学意义(P<0.05)。结论:阻塞性睡眠呼吸暂停综合征与高血压关系密切,慢性间歇缺氧是引起高血压的核心机制。

The Clinical Relationship Analysis between Obstructive Sleep Apnea Syndrome (OSAHS) and Hypertension

Objective: To research the clinical relationship and mechanism between obstructive sleep apnea syndrome(OSAHS) and hypertension.Method: 258 patients were allocated to pure treating sleep apnea(N) and Pure OSAHS(O) and OSAHS and hypertension(O+H) according to patient’s intention and condition.Three groups of patients with clinical foundation data collection,ESS questionnaire survey and EP score,polysomnography monitoring and blood pressure measurement.Results: The difference of which all three groups on age,sex,smoking,drinking was no significant difference(P<0.05).But compared with control group,OSAHS group and OSAHS + HT group,the difference of BMI and NC was statistically significant(P<0.05);The difference of which OSAHS group and OSAHS + HT group compared with the control group on AHI,Ts90,LsaO2,MsaO2 is statistically significant(P<0.05);The difference of which OSAHS group and OSAHS + HT group compared with control group on systolic and diastolic blood pressure before and after sleeping,is statistically significant(P<0.05).Conclusion: We concluded that OSAHS is associated with hypertension closely,chronic intermittent hypoxia is the cardinal mechanism which causing hypertension.