VEGF-C 在口腔鳞状细胞癌中的表达及其意义

目的:检测血管内皮生长因子-C(VEGF-C)在口腔鳞状细胞癌(鳞癌)和癌旁组织中的表达情况,探讨VEGF-C在口腔鳞癌的增殖、浸润和淋巴转移中的作用。方法:采用免疫组化方法检测60例口腔鳞癌病人癌组织和癌旁组织中VEGF-C的表达,应用图像分析系统进行分析,用Spearman相关分析研究其与病变部位、肿瘤大小、病理分级、临床分期及颈淋巴结转移之间的关系。结果:口腔鳞癌组织VEGF-C的表达明显高于癌旁组织(u=7.747,P<0.01),其表达强度与临床分期及淋巴结转移密切相关(r=0.564、0.706,P<0.05),与病变部位、大小、病理分级无关。结论:口腔鳞癌细胞分泌VEGF-C诱导癌周淋巴管增生扩张是发生区域淋巴结转移的重要因素之一,VEGF-C有望作为早期临床判断和预测颈淋巴结转移的指标之一。

Expression and Meaning of VEGF-C in Oral Squamous Cell Carcinoma

Objective: To investigate the expression of vascular endothelial growth factor C(VEGF-C) in oral squamous cell carcinoma(OSCC) and adjacent tissues,and to investigate the effect of the VEGF-C in the proliferation,invasion and metastasis of OSCC.Methods: Image analysis system was used to detect the expression of VEGF-C in OSCC.Adjacent normal tissues in 60 patients were determined by immunohistochemical staining,then the relationship with lesion,size,pathologic grade,clinical stage and neck lymph node metastasis was analyzed.Results:There was significant difference between the OSCC and the adjacent tissues in the expression ofVEGF-C(u=7.747,P < 0.01),which indicated there was close relation between the VEGF-C expression intensity and the proliferation,invasion and metastasis of OSCC.Conclusion: The VEGF-C expressed by OSCC plays an important role in regional lymph node metastasis by inducing Cancer-week lymphatic hyperplasia expansion.